ADAMTS4 Antibody

Catalog Number: ASA-B0038
Lead time: 1 week
$260.00

Overview

Long Name

Antibody Type

Antibody Isotype

Host

Species Reactivity

Validated Applications

Purification 

ADAM metallopeptidase with thrombospondin type 1 motif, 4 Polyclonal IgG Rabbit Human, Mouse, Rat WB Immunogen affinity purified.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human ADAMTS4(820-837aa RRAQILEILRRRPWAGRK), different from the related rat and mouse sequences by three amino acids.

Properties

Form

Lyophilized

Size

100 µg/vial

Contents

Antibody is lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal and 0.05 mg NaN3. *carrier free antibody available upon request.

Concentration

Reconstitute with 0.2 ml sterile dH2O (500 µg/ml final concentration).

Storage

At -20 °C for 12 months, as supplied. Store reconstituted antibody at 2-8 °C for one month. For long-term storage, aliquot and store at -20 °C. Avoid repeated freezing and thawing.

Additional Information Regarding the Antigen

Gene

ADAMTS4

Protein

A disintegrin and metalloproteinase with thrombospondin motifs 4(ADAM-TS 4/ADAM-TS4/ADAMTS-4)

Uniprot ID

O75173

Function

Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-

Tissue Specificity

Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles. Isoform 2 is detected in osteoarthritic synovium.

Sub-cellular localization

Secreted, extracellular space, extracellular matrix .

Sequence Similarities

Contains 1 disintegrin domain.

Aliases

A disintegrin and metalloproteinase with thrombospondin motifs 4 antibody|A disintegrin like and metalloprotease(reprolysin type) with thrombospondin type 1 motif 4 antibody|A disintegrin like and metalloprotease with thrombospondin type 1 motif 4 antibody|ADAM metallopeptidase with thrombospondin type 1 motif 4 antibody|ADAM TS 4 antibody|ADAM TS4 antibody|ADAM-TS 4 antibody|ADAM-TS4 antibody|ADAMTS 2 antibody|ADAMTS 4 antibody|ADAMTS-4 antibody|ADAMTS2 antibody|ADAMTS4 antibody|ADAMTS4 protein antibody|ADMP 1 antibody|ADMP-1 antibody|ADMP1 antibody|Aggrecanase 1 antibody|Aggrecanase-1 antibody|Aggrecanase1 antibody|ATS4_HUMAN antibody|KIAA0688 antibody

Application Details

Application Concentration* Species Validated Using**
Western blot 0.1-0.5μg/ml Human, Mouse, Rat AssaySolution's ECL kit


AssaySolution recommends Rabbit Chemiluminescent WB Detection Kit (AKIT001B) for Western blot. *Blocking peptide can be purchased at $65. Contact us for more information

Anti-ADAMTS4 antibody, ASA-B0038, Western blotting
Lane 1: Rat Brain Tissue Lysate
Lane 2: Mouse Brain Tissue Lysate
 
 
 
 
 
 
 
Assay Solution's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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