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ELISA
Ultrasensitive Detection iPCR Kit
Bone Biomarkers
Cardiac Biomarkers
Tumor Biomarkers
ImmunoMetabolism Biomarkers
Assay Kits
Magnetic beads
Magnetic beads for protein/antibody and DNA purification, immunoprecipitation, CHIP assay
The Excel table for antibody affinity comparison
Antibodies
Immunohistochemistry (IHC) - Premier
Immunohistochemistry (IHC)
Secondary Antibodies
Flow Cytometry
Conjugated Antibodies
Unconjugated Antibodies
Isotype Control Antibodies
Western Blot
Matched Antibody Pairs
Human
Mouse
Rat
Swine
Chicken
Protein
Magnetic Beads
Proteins and Peptides
Services
Support
Catalogs
Articles
Immunohistochemistry (IHC)
Immunometabolism Biomarkers
Blood Coagulation and Anemia Biomarkers
Bone Biomarkers
Cardiac Biomarkers
Tumor Biomarkers
Promotion Events
Contact
Categories
ELISA
Assay Kits
Magnetic beads
Antibodies
Immunohistochemistry (IHC) - Premier
Immunohistochemistry (IHC)
Secondary Antibodies
Flow Cytometry
Western Blot
Matched Antibody Pairs
Protein
Services
Support
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Immunohistochemistry (IHC) - Premier
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BRAF V600E (Premier)
BRAF V600E (Premier)
100 µL
Catalog Number:
ASA-S1004
Old price:
$435.00
Price:
$
399.50
Qty:
Product Attachments
Datasheet BRAF V600E
Products specifications
Description
Serine/threonine-protein kinase B-Raf (BRAF) is a cytoplasmic serine-threonine kinase of the RAF family which mediates downstream cellular responses to growth signals through the mitogen-activated protein kinase (MAPK) signaling pathway. Oncogenic mutations in the BRAF gene, 80% of which are a single V600E substitution within the kinase domain, constitutively activate the MAPK signaling pathway and result in increased cell proliferation and apoptosis resistance. The V600E mutation is observed in colorectal cancer, non-Hodgkin lymphoma, papillary thyroid carcinoma, malignant melanoma, non-small-cell lung carcinoma, and lung adenocarcinoma. BRAF V600E is therefore an important immunohistochemical marker for tumor diagnosis and prognosis.
Source
Mouse Monoclonal
Positive Control
Colorectal Adenocarcinoma, Thyroid Papillary Carcinoma with the BRAF V600E Mutation
Dilution Range
1:100 - 1:200
Assay Solution's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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