Human BMP-6 ELISA Kit

Catalog Number: AYQ-E10454

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Background	Bone morphogenetic protein 6 is a protein that in humans is encoded by the BMP6 gene.The protein encoded by this gene is a member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce the growth of bone and cartilage. BMP6 is able to induce all osteogenic markers in mesenchymal stem cells.The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. As of April 2009, an additional function of BMP6 has been identified as described in Nature Genetics. BMP6 is the key regulator of hepcidin, the small peptide secreted by the liver which is the major regulator of iron metabolism in mammals.
Typical Data	ELISA: Human BMP-6 ELISA Kit (Colorimetric) These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
Applications	ELISA
Sample Volume	50-100ul
Suitable Sample Type	serum, plasma, tissue homogenates, cell lysate, cell culture medium.
Assay Type	Sandwich ELISA
Intra Assay	CV%<8%
Inter Assay	CV%<10%
Sensitivity	125 pg/ml
Standard Curve Range	156.25--10000 pg/ml
Notes	Please contact our Technical Services with any questions regarding species reactivity
Kit Components	Assay plate (12 x 8 coated Microwells), Standard (Freeze dried), Biotin-antibody (60 x concentrate), HRP-avidin (20 x concentrate), Biotin-antibody Diluent, HRP-avidin Diluent, Sample Diluent, Wash Buffer (20 x concentrate), TMB Substrate, Stop Solution, Adhesive Strip (For 96 wells), Instruction manual
Specificity	This assay has high sensitivity and excellent specificity for Human BMP-6. No significant cross-reactivity or Human BMP-6 and analogues was observed.
Species	Human
Synonym	BMP6; BMP-6; bone morphogenetic protein 6; vegetal related growth factor (TGFB-related); vegetal-related (TGFB related) cytokine; VG-1-R; VG-1-related protein; Vg1-related sequence; VGR; VGR1; Vgr-1
Gene Symbol	BMP6
Gene ID	654
Storage	Store the unopened product at 2 - 8° C. Protect from light. Do not use past expiration date.

Assay Solution's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Human BMP-6 ELISA Kit

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