PNMT Antibody

PNMT is an enzyme located in the adrenal medulla and it catalyzes the final step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). PNMT has beta-carboline 2N-methyltransferase activity. PNMT takes part in regulating epinephrine production. Glucocorticoid receptors form multimers of PNMT independent of the DNA binding domain. PNMT expression is regulated late in mouse gestation by AP2-alpha and glucocorticoids.

Catalog Number: AS-P04335

Lead time: 3-4 business days

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Products specifications

Applications	The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500.
Synonyms	PENT, PNMTase, Noradrenaline-N-methyltransferase, Phenylethanolamine N-methyltransferase, PNMT, MGC34570.
Type	Mouse Anti Human Monoclonal.
Clone	PAT1C11.
Immunogen	Anti-human PNMT, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human ADK amino acids 1-282 purified from E. coli.
Ig Subclass	Mouse IgG1 heavy chain and k light chain.
Purification Method	PNMT antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Protein formulation	1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
Storage Procedures	For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.