Gene | YBX1 |
Protein | Nuclease-sensitive element-binding protein 1 |
Uniprot ID | P67809 |
Function | Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro. |
Tissue Specificity | |
Sub-cellular localization | Cytoplasm. Nucleus. Cytoplasmic granule. |
Sequence Similarities | Contains 1 CSD (cold-shock) domain. |
Aliases | BP 8 antibody|CBF-A antibody|CCAAT binding transcription factor I subunit A antibody|CCAAT-binding transcription factor I subunit A antibody|CSDA2 antibody| CSDB antibody|DBPB antibody|DNA binding protein B antibody|DNA-binding protein B antibody|EFI-A antibody| Enhancer factor I subunit A antibody|MDR NF1 antibody|MGC104858 antibody|MGC110976 antibody|MGC117250 antibody|NSEP 1 antibody|NSEP1 antibody|Nuclease sensitive element binding protein 1 antibody|Nuclease-sensitive element-binding protein 1 antibody|p50 antibody| Q15905 antibody|Y-box binding protein 1 antibody|Y-box transcription factor antibody|Y-box-binding protein 1 antibody|YB 1 antibody|YB-1 antibody| YBOX1_HUMAN antibody| YBX 1 antibody|YBX1 antibody |
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Anti- YB1 antibody, ASA-B2003, Western blotting
All lanes: Anti YB1 (ASA-B2003) at 0.5ug/ml
Lane 1: Rat Liver Tissue Lysate at 50ug
Lane 2: Mouse Liver Tissue Lysate at 50ug
Lane 3: SMMC Whole Cell Lysate at 40ug
Lane 4: RH35 Whole Cell Lysate at 40ug
Lane 5: HEPG2 Whole Cell Lysate at 40ug
Predicted bind size: 36KD
Observed bind size: 50KD
Anti- YB1 antibody, ASA-B2003,IHC(P)
IHC(P): Mouse Testis Tissue
Anti- YB1 antibody, ASA-B2003,IHC(P)
IHC(P): Rat Testis Tissue
